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Lyra Vital
5-Amino-1MQ — lyophilized powder in a Lyra Vital research vial on black marble
Lyophilized powder

Cellular

5-Amino-1MQ

5-Amino-1-methylquinolinium (NNMT inhibitor)

Also known as 5-Amino-1-methylquinolinium

5-Amino-1MQ is a small-molecule quinolinium compound, not a peptide — worth stating plainly, since it is routinely sold alongside peptides. It is a cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide and thereby diverts it away from the NAD+ salvage pathway. Research interest follows from NNMT overexpression in adipose tissue and the hypothesis that inhibition preserves both methyl donor pools and NAD+ precursor availability.

Research applications

  • NNMT enzyme inhibition and selectivity assays
  • NAD+ salvage pathway flux studies
  • S-adenosylmethionine and methyl donor pool measurement
  • Adipocyte metabolic studies

Storage

Store at -20°C protected from light and moisture.

Reconstitution

Solubility differs from peptides — consult the COA for the appropriate solvent system rather than defaulting to bacteriostatic water.

Bacteriostatic water, 10mL → · Work out the volume →

Published literature

Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.

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Purity
Per published certificate
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How 5-Amino-1MQ compares

Side-by-side against the compounds researchers most often weigh it against, with price per milligram, mechanism and the published certificate for each.

NAD+ vs 5-Amino-1MQ

Direct NAD+ supply against inhibition of the enzyme that depletes its precursor — two opposite strategies toward the same pool.

5-Amino-1MQ vs Epitalon

5-Amino-1MQ vs Glutathione

5-Amino-1MQ vs MOTS-c

Research goals that include 5-Amino-1MQ

The research areas this compound is grouped under, each with the other compounds studied alongside it and the published certificates for the group.

Metabolic Regulation

Studied alongside Retatrutide, Semaglutide, Tirzepatide, Cagrilintide

5-Amino-1MQ

From $49