Cellular
MOTS-c
MOTS-c (Mitochondrial ORF of the 12S rRNA type-c)
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene — one of a small class of mitochondrial-derived peptides that upended the assumption that the mitochondrial genome encodes only respiratory chain components. Research has focused on its translocation to the nucleus under metabolic stress and its role in AMPK-dependent signaling.
Research applications
- AMPK pathway activation studies
- Mitochondrial-nuclear retrograde signaling research
- Folate-methionine cycle interaction assays
- Exercise physiology and metabolic stress models
Storage
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
Reconstitution
Reconstitute with bacteriostatic water directed down the vial wall. Swirl gently.
Published literature
306 papers indexed on PubMed for MOTS-c. Showing 6, reviews first.
- 01MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation
Zheng Y et al. · Front Endocrinol (Lausanne) · 2023
- 02MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases
Mohtashami Z et al. · Int J Mol Sci · 2022
- 03MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism
Lee C et al. · Free Radic Biol Med · 2016
- 04
- 05Mitochondria-derived peptide MOTS-c restores mitochondrial respiration in type 2 diabetic heart
Pham T et al. · Front Physiol · 2025
- 06
Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.
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How MOTS-c compares
Side-by-side against the compounds researchers most often weigh it against, with price per milligram, mechanism and the published certificate for each.
MOTS-c
From $49