Cellular
SS-31
SS-31 (Elamipretide)
Also known as Elamipretide · MTP-131 · Bendavia
SS-31 is a cell-permeable tetrapeptide that concentrates in the inner mitochondrial membrane through interaction with cardiolipin, a phospholipid essential to cristae architecture and respiratory supercomplex assembly. Its alternating aromatic-cationic motif drives membrane targeting independent of mitochondrial membrane potential — a mechanistic distinction from earlier targeting strategies such as TPP+ conjugation.
Research applications
- Cardiolipin binding and cristae morphology studies
- Mitochondrial respiration and ATP synthesis assays
- Reactive oxygen species and oxidative stress models
- Ischemia-reperfusion injury research
Storage
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
Reconstitution
Reconstitute with bacteriostatic water directed down the vial wall. Swirl gently.
Published literature
462 papers indexed on PubMed for SS-31. Showing 6, reviews first.
- 01Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
Mendias CL, Awan TM · Sports Med · 2026
- 02Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential
Tung C et al. · Int J Mol Sci · 2025
- 03Mitochondrial Dysfunction: The Silent Catalyst of Kidney Disease Progression
Pavlović N et al. · Cells · 2025
- 04Beyond the injection: delivery systems reshaping retinal disease management
Rowe LW et al. · Expert Opin Pharmacother · 2025
- 05Innovative technologies for the treatment of dry age-related macular degeneration (AMD) - modern therapeutic perspectives and their future
Ciszewski P et al. · Rom J Ophthalmol · 2025
- 06Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD)
Nashine S · Cells · 2021
Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.
Related compounds
MOTS-c
10mg · COA published
16-amino-acid mitochondrial-derived peptide studied for AMPK activation and metabolic homeostasis.
- Purity
- 99.025%
- 5 lab certificates
Epitalon
10–50mg · COA published
Synthetic tetrapeptide studied for telomerase activity and pineal regulation in cell and animal models.
- Purity
- 99.464%
- 7 lab certificates
NAD+
500–1000mg · COA published
Essential redox coenzyme and substrate for sirtuins and PARPs — central to metabolic and DNA repair research.
- Purity
- Per published certificate
- 10 lab certificates
Glutathione
750–1500mg · COA published
Endogenous thiol tripeptide and the principal intracellular antioxidant, central to redox buffering research.
- Purity
- 99.07%
- 1 lab certificate
The certificate comes first
Every compound’s independent laboratory analysis is published before you buy, not sent on request.
Verify it without us
Each certificate carries a laboratory key. Enter a batch code and check it at the lab directly.
Ships from Orlando, FL
Orders dispatch within 1 business day of cleared payment, with tracking emailed when the parcel is handed to the carrier. Track any order, account or not.
A person answers
Write to [email protected] and a human replies — no ticket bot, no queue number.
How SS-31 compares
Side-by-side against the compounds researchers most often weigh it against, with price per milligram, mechanism and the published certificate for each.
Research goals that include SS-31
The research areas this compound is grouped under, each with the other compounds studied alongside it and the published certificates for the group.
SS-31
From $49