Cellular
NAD+
NAD+ (Nicotinamide adenine dinucleotide)
NAD+ is a dinucleotide coenzyme present in all living cells, functioning both as an electron carrier in redox reactions and as a consumed substrate for sirtuins, PARPs, and CD38. It is not a peptide. Research interest in the longevity context follows from the observation that tissue NAD+ concentration declines with age, and from the dependence of sirtuin activity on NAD+ availability.
Research applications
- Sirtuin activity and deacetylation assays
- PARP-mediated DNA repair studies
- Mitochondrial respiration and redox state measurement
- CD38 and NAD+ consumption pathway research
Storage
Store lyophilized at -20°C protected from light and moisture. NAD+ is hygroscopic and degrades in solution faster than most peptides — prepare fresh where the assay permits.
Reconstitution
Reconstitute with bacteriostatic or sterile water. Solutions are less stable than peptide solutions; use promptly.
Published literature
85,360 papers indexed on PubMed for NAD+. Showing 6, reviews first.
- 01NAD metabolism: Role in senescence regulation and aging
Chini CCS et al. · Aging Cell · 2024
- 02Nicotinamide Adenine Dinucleotide (NAD(+))-Dependent Signaling in Neurological Disorders
Bresque M et al. · Antioxid Redox Signal · 2023
- 03The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
Song Q et al. · Adv Nutr · 2023
- 04Nicotinamide adenine dinucleotide metabolism: driving or counterbalancing inflammatory bowel disease?
Xue X et al. · FEBS Lett · 2023
- 05The complexity of nicotinamide adenine dinucleotide (NAD), hypoxic, and aryl hydrocarbon receptor cell signaling in chronic kidney disease
Curran CS, Kopp JB · J Transl Med · 2023
- 06Nicotinamide Adenine Dinucleotide (NAD) Metabolism as a Relevant Target in Cancer
Navas LE, Carnero A · Cells · 2022
Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.
Related compounds
MOTS-c
10mg · COA published
16-amino-acid mitochondrial-derived peptide studied for AMPK activation and metabolic homeostasis.
- CAS
- 1627580-64-7
- MW
- 2174.61
- Purity
- Per published certificate
SS-31
10mg · COA published
Mitochondria-targeting tetrapeptide with high affinity for cardiolipin on the inner mitochondrial membrane.
- CAS
- 736992-21-5
- MW
- 639.79
- Purity
- Per published certificate
Epitalon
10–50mg · COA published
Synthetic tetrapeptide studied for telomerase activity and pineal regulation in cell and animal models.
- CAS
- 307297-39-8
- MW
- 390.35
- Purity
- Per published certificate
Glutathione
750–1500mg · COA published
Endogenous thiol tripeptide and the principal intracellular antioxidant, central to redox buffering research.
- CAS
- 70-18-8
- MW
- 307.32
- Purity
- Per published certificate
How NAD+ compares
Side-by-side against the compounds researchers most often weigh it against, with price per milligram, mechanism and the published certificate for each.
NAD+ vs 5-Amino-1MQ
Direct NAD+ supply against inhibition of the enzyme that depletes its precursor — two opposite strategies toward the same pool.
NAD+ vs Glutathione
The two dominant redox cofactors in cell biology, routinely confused because both are described as antioxidants — only one of them actually is.
Epitalon vs NAD+
MOTS-c vs NAD+
NAD+
From $59