Cellular
Epitalon
Epitalon (Epithalon)
Also known as Epithalone · AEDG peptide
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from research on pineal gland extracts. Published work has examined effects on telomerase expression in somatic cell cultures and circadian regulation in aged animals. A candid note on the evidence base: much of the foundational literature comes from a single institute and is not widely independently replicated. Researchers should weight it accordingly.
Research applications
- Telomerase activity assays in fibroblast culture
- Melatonin rhythm and pineal function studies
- Cellular senescence marker profiling
- Chromatin structure research in aged cell models
Storage
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
Reconstitution
Reconstitute with bacteriostatic water directed down the vial wall. Swirl gently.
Published literature
70 papers indexed on PubMed for Epitalon. Showing 6, reviews first.
- 01Therapeutic peptides in gerontology: mechanisms and applications for healthy aging
Mavrych V et al. · Front Aging · 2026
- 02Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
Araj SK et al. · Int J Mol Sci · 2025
- 03
- 04Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
Al-Dulaimi S et al. · Biogerontology · 2025
- 05The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy
Gatta M et al. · Stem Cell Rev Rep · 2025
- 06Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro
Yue X et al. · Aging (Albany NY) · 2022
Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.
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How Epitalon compares
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Research goals that include Epitalon
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Epitalon
From $39