5-Amino-1MQ vs Epitalon
Cellular
5-Amino-1MQ
Small-molecule NNMT inhibitor studied for effects on cellular methylation capacity and NAD+ salvage.
Cellular
Epitalon
Synthetic tetrapeptide studied for telomerase activity and pineal regulation in cell and animal models.
Side by side
| Dimension | 5-Amino-1MQ | Epitalon |
|---|---|---|
| Molecular weight A 2.5× difference in mass — these are not comparable on a milligram-for-milligram basis. | 159.21 g/mol | 390.35 g/mol |
| Size class | small molecule / short peptide | small molecule / short peptide |
| CAS number | 42464-96-0 | 307297-39-8 |
| Research area | longevity | longevity |
| Sequence | Not published as a linear sequence | Ala-Glu-Asp-Gly |
| Available sizes | 10mg | 10mg, 50mg |
| Entry price | $49 | $39 |
| Cost per mg Cost per milligram differs by more than 3×. Compare against the concentrations your protocol actually requires, not the headline vial price. | $4.90 | $1.38 |
Mechanism
5-Amino-1MQ
5-Amino-1MQ is a small-molecule quinolinium compound, not a peptide — worth stating plainly, since it is routinely sold alongside peptides. It is a cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide and thereby diverts it away from the NAD+ salvage pathway. Research interest follows from NNMT overexpression in adipose tissue and the hypothesis that inhibition preserves both methyl donor pools and NAD+ precursor availability.
Epitalon
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from research on pineal gland extracts. Published work has examined effects on telomerase expression in somatic cell cultures and circadian regulation in aged animals. A candid note on the evidence base: much of the foundational literature comes from a single institute and is not widely independently replicated. Researchers should weight it accordingly.
Evidence quality
Mechanism is not the same as evidence. Where we have assessed the literature, the verdict is stated plainly.
5-Amino-1MQ
Evidence base: minimal. Three indexed results for the compound, none of which characterise it directly. The NNMT target is well studied; the inhibitor is not. Treat every claim about this compound as an inference from enzyme biology until direct work exists.
Full research reference →Epitalon
Evidence base: moderate volume, narrow provenance. A large share originates from one group. The telomerase mechanism is the most testable claim and has recently attracted work from outside that group, which is where replication should be sought.
Full research reference →Research applications
5-Amino-1MQ
- NNMT enzyme inhibition and selectivity assays
- NAD+ salvage pathway flux studies
- S-adenosylmethionine and methyl donor pool measurement
- Adipocyte metabolic studies
Epitalon
- Telomerase activity assays in fibroblast culture
- Melatonin rhythm and pineal function studies
- Cellular senescence marker profiling
- Chromatin structure research in aged cell models
Common questions
What is the difference between 5-Amino-1MQ and Epitalon?
5-Amino-1MQ is small-molecule NNMT inhibitor studied for effects on cellular methylation capacity and NAD+ salvage. Epitalon is synthetic tetrapeptide studied for telomerase activity and pineal regulation in cell and animal models. They differ in molecular weight (159.21 vs 390.35 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, 5-Amino-1MQ or Epitalon?
Epitalon is lower at approximately $1.38 per milligram at its best tier, against $4.90 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can 5-Amino-1MQ and Epitalon be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should 5-Amino-1MQ and Epitalon be stored?
Store at -20°C protected from light and moisture. For Epitalon: Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
Which has the stronger evidence base?
5-Amino-1MQ — Evidence base: minimal. Three indexed results for the compound, none of which characterise it directly. The NNMT target is well studied; the inhibitor is not. Treat every claim about this compound as an inference from enzyme biology until direct work exists. Epitalon — Evidence base: moderate volume, narrow provenance. A large share originates from one group. The telomerase mechanism is the most testable claim and has recently attracted work from outside that group, which is where replication should be sought.
All products sold on this website are intended for research and identification purposes only. These products are not intended for human dosing, injection, or ingestion.
Comparison generated from Lyra Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.