Tissue Repair
TB-500
TB-500 (Thymosin Beta-4)
Thymosin beta-4 is a 43-amino-acid peptide and the principal G-actin sequestering molecule in mammalian cells. Its central mechanism is binding monomeric actin and regulating polymerization, which underlies its research relevance to cell motility, wound models, and angiogenesis. The actin-binding domain is localized to a short internal sequence (LKKTETQ), and some suppliers sell fragments of this region rather than the full peptide — a distinction worth confirming on any COA.
Research applications
- Actin polymerization and cytoskeletal dynamics assays
- Endothelial cell migration and tube formation studies
- Corneal and dermal wound model research
- Inflammatory cytokine modulation studies
Storage
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
Reconstitution
Reconstitute with bacteriostatic water directed down the vial wall. Swirl gently until fully dissolved.
Published literature
668 papers indexed on PubMed for TB-500. Showing 6, reviews first.
- 01Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Rahman OF et al. · J Am Acad Orthop Surg Glob Res Rev · 2026
- 02Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians
Mayfield CK et al. · Am J Sports Med · 2026
- 03Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
Mendias CL, Awan TM · Sports Med · 2026
- 04Neurotrophic keratopathy: current challenges and future prospects
NaPier E et al. · Ann Med · 2022
- 05Thymosin-β4: A key modifier of renal disease
Vasilopoulou E et al. · Expert Opin Biol Ther · 2018
- 06Thymosin β4 Promotes Dermal Healing
Kleinman HK, Sosne G · Vitam Horm · 2016
Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.
Related compounds
BPC-157
5–10mg · COA published
Synthetic pentadecapeptide derived from a gastric juice protein, widely studied for cytoprotection and angiogenic signaling.
- CAS
- 137525-51-0
- MW
- 1419.53
- Purity
- Per published certificate
GHK-Cu
50–100mg · COA published
Naturally occurring copper-binding tripeptide studied for extracellular matrix remodeling and gene expression modulation.
- CAS
- 89030-95-5
- MW
- 400.9
- Purity
- Per published certificate
Wolverine Blend
10mg · COA published
Co-formulated pentadecapeptide and thymosin beta-4 fragment, the two most frequently co-administered compounds in tissue-repair literature, supplied in a single vial.
- CAS
- 137525-51-0 / 77591-33-4
- MW
- 1419.53
- Purity
- Per published certificate
Glow Blend
70mg · COA published
Three-compound co-formulation pairing the copper-binding tripeptide GHK-Cu with BPC-157 and TB-500, studied together in extracellular matrix and tissue-remodeling contexts.
- CAS
- 89030-95-5 / 137525-51-0 / 77591-33-4
- MW
- 400.9
- Purity
- Per published certificate
How TB-500 compares
Side-by-side against the compounds researchers most often weigh it against, with price per milligram, mechanism and the published certificate for each.
TB-500
From $38