KLOW Blend vs TB-500
Tissue Repair
KLOW Blend
Four-compound co-formulation: the Glow trio of GHK-Cu, BPC-157 and TB-500, plus the α-MSH-derived tripeptide KPV, studied together in tissue-remodeling and inflammatory-signaling contexts.
Tissue Repair
TB-500
Synthetic thymosin beta-4, a 43-amino-acid actin-sequestering peptide studied for cell migration and angiogenesis.
Side by side
| Dimension | KLOW Blend | TB-500 |
|---|---|---|
| Molecular weight A 12.4× difference in mass — these are not comparable on a milligram-for-milligram basis. | 400.9 g/mol | 4963.44 g/mol |
| Size class | small molecule / short peptide | long peptide |
| CAS number | 89030-95-5 / 137525-51-0 / 77591-33-4 / 67727-97-3 | 77591-33-4 |
| Research area | repair | repair |
| Sequence | Not published as a linear sequence | Not published as a linear sequence |
| Available sizes | 80mg | 5mg, 10mg |
| Entry price | $124 | $38 |
| Cost per mg Cost per milligram differs by more than 3×. Compare against the concentrations your protocol actually requires, not the headline vial price. | $1.55 | $6.40 |
Mechanism
KLOW Blend
KLOW extends the Glow formulation with KPV, the C-terminal tripeptide (residues 11-13) of alpha-melanocyte-stimulating hormone. GHK-Cu is studied for copper delivery and extracellular matrix remodeling, BPC-157 for angiogenic and cytoprotective signaling, and TB-500 for actin sequestration and cell migration; KPV adds a line of work on NF-κB pathway inhibition in epithelial models. Each vial holds 50mg GHK-Cu, 10mg BPC-157, 10mg TB-500 and 10mg KPV. Co-formulation is a handling convenience; each compound's evidence base stands on its own.
TB-500
Thymosin beta-4 is a 43-amino-acid peptide and the principal G-actin sequestering molecule in mammalian cells. Its central mechanism is binding monomeric actin and regulating polymerization, which underlies its research relevance to cell motility, wound models, and angiogenesis. The actin-binding domain is localized to a short internal sequence (LKKTETQ), and some suppliers sell fragments of this region rather than the full peptide — a distinction worth confirming on any COA.
Evidence quality
Mechanism is not the same as evidence. Where we have assessed the literature, the verdict is stated plainly.
TB-500
Evidence base: the actin-sequestering mechanism is well established and independently replicated. Claims specific to the LKKTETQ fragment rest on a considerably thinner literature than those for full-length Tβ4.
Full research reference →Research applications
KLOW Blend
- Extracellular matrix remodeling assays
- Inflammatory cytokine and NF-κB pathway studies
- Copper-peptide gene expression modulation
- Multi-pathway repair protocol design
TB-500
- Actin polymerization and cytoskeletal dynamics assays
- Endothelial cell migration and tube formation studies
- Corneal and dermal wound model research
- Inflammatory cytokine modulation studies
Common questions
What is the difference between KLOW Blend and TB-500?
KLOW Blend is four-compound co-formulation: the Glow trio of GHK-Cu, BPC-157 and TB-500, plus the α-MSH-derived tripeptide KPV, studied together in tissue-remodeling and inflammatory-signaling contexts. TB-500 is synthetic thymosin beta-4, a 43-amino-acid actin-sequestering peptide studied for cell migration and angiogenesis. They differ in molecular weight (400.9 vs 4963.44 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, KLOW Blend or TB-500?
KLOW Blend is lower at approximately $1.55 per milligram at its best tier, against $6.40 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can KLOW Blend and TB-500 be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should KLOW Blend and TB-500 be stored?
Store lyophilized powder at -20°C protected from light. Copper-containing peptides are light-sensitive — keep vials in the carton. Reconstituted solution stable at 2-8°C for up to 30 days. For TB-500: Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
Which has the stronger evidence base?
TB-500 — Evidence base: the actin-sequestering mechanism is well established and independently replicated. Claims specific to the LKKTETQ fragment rest on a considerably thinner literature than those for full-length Tβ4. Where we have not published a formal evidence assessment, treat the literature as requiring your own appraisal.
All products sold on this website are intended for research and identification purposes only. These products are not intended for human dosing, injection, or ingestion.
Comparison generated from Lyra Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.