Specialty
PT-141
PT-141 (Bremelanotide)
PT-141 is a cyclic heptapeptide and the deaminated metabolite of melanotan II, acting as an agonist at melanocortin receptors with principal research interest at MC4R. Unlike melanotan II it lacks significant MC1R-mediated pigmentation activity, making it a cleaner tool for isolating MC4R-mediated central effects. Its mechanism is centrally mediated rather than vascular, which distinguishes it from PDE5-targeting compounds.
Research applications
- MC4R and MC3R binding and selectivity assays
- Central melanocortin pathway signaling studies
- Comparative receptor profiling against melanotan II
Storage
Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C for up to 30 days.
Reconstitution
Reconstitute with bacteriostatic water down the vial wall. Swirl gently.
Published literature
120 papers indexed on PubMed for PT-141. Showing 6, reviews first.
- 01Targeting the central melanocortin system for the treatment of metabolic disorders
Sweeney P et al. · Nat Rev Endocrinol · 2023
- 02Bremelanotide for Treatment of Female Hypoactive Sexual Desire
Edinoff AN et al. · Neurol Int · 2022
- 03Medical Treatment of Female Sexual Dysfunction
Nappi RE et al. · Urol Clin North Am · 2022
- 04Hypoactive Sexual Desire Disorder in Women: Physiology, Assessment, Diagnosis, and Treatment
Pettigrew JA, Novick AM · J Midwifery Womens Health · 2021
- 05Bremelanotide: First Approval
Dhillon S, Keam SJ · Drugs · 2019
- 06
Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.
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Reconstitution Solution – for Laboratory Use
10mL · Sterile
Sterile water preserved with 0.9% benzyl alcohol — the standard laboratory solvent for reconstituting lyophilized research compounds.
- Volume
- 10mL
- Grade
- Sterile
How PT-141 compares
Side-by-side against the compounds researchers most often weigh it against, with price per milligram, mechanism and the published certificate for each.
PT-141
From $44