Specialty
KPV
KPV (α-MSH 11-13 tripeptide)
Also known as Lys-Pro-Val
KPV is the C-terminal tripeptide (residues 11-13) of alpha-melanocyte-stimulating hormone. Its research interest stems from retaining anti-inflammatory activity attributed to the parent hormone while lacking the melanocortin receptor binding responsible for pigmentation effects — making it a useful tool for separating those two activities. Work has examined NF-κB pathway inhibition in intestinal epithelial models.
Research applications
- NF-κB signaling pathway inhibition assays
- Intestinal epithelial inflammation models
- PepT1 transporter-mediated uptake studies
- Cytokine expression profiling
Storage
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
Reconstitution
Reconstitute with bacteriostatic water directed down the vial wall. Swirl gently.
Published literature
81 papers indexed on PubMed for KPV. Showing 6, reviews first.
- 01A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon
Zhao Y et al. · Acta Biomater · 2022
- 02Are melanocortin peptides future therapeutics for cutaneous wound healing?
Böhm M, Luger T · Exp Dermatol · 2019
- 03Structure-antifungal activity relationship of His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 and analogues
Masman MF et al. · Bioorg Med Chem · 2008
- 04
- 05PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
Dalmasso G et al. · Gastroenterology · 2008
- 06Conformational analysis of tripeptide Ac-Lys-Pro-Val-NH2, COOH-terminal sequence of alpha-MSH
Chavatte P et al. · J Pharm Pharmacol · 2001
Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.
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Bacteriostatic Water – for Laboratory Use
10mL, 3mL · Sterile
Reconstitution solution for research: bacteriostatic water, sterile with 0.9% benzyl alcohol. 10mL and 3mL multi-use vials from $9.
- Volume
- 10mL, 3mL
- Grade
- Sterile
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How KPV compares
Side-by-side against the compounds researchers most often weigh it against, with price per milligram, mechanism and the published certificate for each.
Research goals that include KPV
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KPV
From $49