TB-500 vs Wolverine Blend
Tissue Repair
TB-500
Synthetic thymosin beta-4, a 43-amino-acid actin-sequestering peptide studied for cell migration and angiogenesis.
Tissue Repair
Wolverine Blend
Co-formulated pentadecapeptide and thymosin beta-4 fragment, the two most frequently co-administered compounds in tissue-repair literature, supplied in a single vial.
Side by side
| Dimension | TB-500 | Wolverine Blend |
|---|---|---|
| Molecular weight A 3.5× difference in mass — these are not comparable on a milligram-for-milligram basis. | 4963.44 g/mol | 1419.53 g/mol |
| Size class | long peptide | short peptide |
| CAS number | 77591-33-4 | 137525-51-0 / 77591-33-4 |
| Research area | repair | repair |
| Sequence | Not published as a linear sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val / Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES |
| Available sizes | 5mg, 10mg | 10mg |
| Entry price | $38 | $69 |
| Cost per mg | $6.40 | $6.90 |
Mechanism
TB-500
Thymosin beta-4 is a 43-amino-acid peptide and the principal G-actin sequestering molecule in mammalian cells. Its central mechanism is binding monomeric actin and regulating polymerization, which underlies its research relevance to cell motility, wound models, and angiogenesis. The actin-binding domain is localized to a short internal sequence (LKKTETQ), and some suppliers sell fragments of this region rather than the full peptide — a distinction worth confirming on any COA.
Wolverine Blend
This blend combines BPC-157, a synthetic pentadecapeptide derived from a gastric juice protein, with TB-500, a synthetic fragment of thymosin beta-4. The two are the most frequently co-administered pair in the repair literature because they act through entirely different mechanisms: BPC-157 is studied for angiogenic signaling and cytoprotection, while TB-500 is studied for actin sequestration and cell migration. Co-formulation removes a reconstitution step; it is not a claim of synergy, and the underlying evidence for each compound remains separate.
Evidence quality
Mechanism is not the same as evidence. Where we have assessed the literature, the verdict is stated plainly.
TB-500
Evidence base: the actin-sequestering mechanism is well established and independently replicated. Claims specific to the LKKTETQ fragment rest on a considerably thinner literature than those for full-length Tβ4.
Full research reference →Research applications
TB-500
- Actin polymerization and cytoskeletal dynamics assays
- Endothelial cell migration and tube formation studies
- Corneal and dermal wound model research
- Inflammatory cytokine modulation studies
Wolverine Blend
- Comparative angiogenesis and cell-migration assays
- Tendon and ligament repair models
- Actin-sequestration versus cytoprotection pathway separation
- Co-administration protocol design
Common questions
What is the difference between TB-500 and Wolverine Blend?
TB-500 is synthetic thymosin beta-4, a 43-amino-acid actin-sequestering peptide studied for cell migration and angiogenesis. Wolverine Blend is co-formulated pentadecapeptide and thymosin beta-4 fragment, the two most frequently co-administered compounds in tissue-repair literature, supplied in a single vial. They differ in molecular weight (4963.44 vs 1419.53 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, TB-500 or Wolverine Blend?
TB-500 is lower at approximately $6.40 per milligram at its best tier, against $6.90 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can TB-500 and Wolverine Blend be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should TB-500 and Wolverine Blend be stored?
Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days. For Wolverine Blend: Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
Which has the stronger evidence base?
TB-500 — Evidence base: the actin-sequestering mechanism is well established and independently replicated. Claims specific to the LKKTETQ fragment rest on a considerably thinner literature than those for full-length Tβ4. Where we have not published a formal evidence assessment, treat the literature as requiring your own appraisal.
All products sold on this website are intended for research and identification purposes only. These products are not intended for human dosing, injection, or ingestion.
Comparison generated from Lyra Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.