DSIP vs Selank
Neuroactive
DSIP
Nonapeptide isolated from rabbit cerebral venous blood, studied for effects on delta-wave sleep architecture.
Neuroactive
Selank
Heptapeptide analog of tuftsin studied for effects on BDNF expression and GABAergic signaling.
Side by side
| Dimension | DSIP | Selank |
|---|---|---|
| Molecular weight | 848.81 g/mol | 751.88 g/mol |
| Size class | short peptide | short peptide |
| CAS number | 62568-57-4 | 129954-34-3 |
| Research area | cognitive | cognitive |
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Available sizes | 5mg | 5mg, 10mg |
| Entry price | $39 | $36 |
| Cost per mg | $7.80 | $4.90 |
Mechanism
DSIP
DSIP is a nonapeptide originally isolated in the 1970s from the cerebral venous blood of rabbits during induced sleep. Despite fifty years of intermittent study, no specific receptor has been identified and the mechanism remains genuinely unresolved — reported effects span sleep architecture, stress hormone modulation, and thermoregulation without a unifying pathway. Researchers should treat the mechanistic literature as unsettled rather than merely incomplete.
Selank
Selank is a synthetic heptapeptide derived from the immunomodulatory tetrapeptide tuftsin, extended with a Pro-Gly-Pro sequence that substantially increases stability against peptidase degradation. Research has examined its effects on BDNF expression in the hippocampus, monoamine turnover, and enkephalin degradation. The literature originates largely from Russian institutional research and much of the primary work requires translation.
Evidence quality
Mechanism is not the same as evidence. Where we have assessed the literature, the verdict is stated plainly.
DSIP
Evidence base: substantial in volume, concentrated in the 1980s, and explicitly unresolved. No specific receptor has been identified, and the reported activities have not converged on a mechanism. Treat older immunoreactivity findings with care.
Full research reference →Selank
Evidence base: modest and concentrated in provenance, with gene expression as the primary readout rather than behavioural or clinical endpoints. Search results require manual filtering because of name collisions.
Full research reference →Research applications
DSIP
- Sleep architecture and EEG delta-wave studies in animal models
- Corticotropin and stress axis interaction research
- Thermoregulation studies
Selank
- BDNF and neurotrophic factor expression studies
- GABAergic and serotonergic system interaction assays
- Enkephalin degradation and peptidase inhibition research
- Anxiety-related behavioral models in rodents
Common questions
What is the difference between DSIP and Selank?
DSIP is nonapeptide isolated from rabbit cerebral venous blood, studied for effects on delta-wave sleep architecture. Selank is heptapeptide analog of tuftsin studied for effects on BDNF expression and GABAergic signaling. They differ in molecular weight (848.81 vs 751.88 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, DSIP or Selank?
Selank is lower at approximately $4.90 per milligram at its best tier, against $7.80 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can DSIP and Selank be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should DSIP and Selank be stored?
Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C for up to 30 days. For Selank: Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
Which has the stronger evidence base?
DSIP — Evidence base: substantial in volume, concentrated in the 1980s, and explicitly unresolved. No specific receptor has been identified, and the reported activities have not converged on a mechanism. Treat older immunoreactivity findings with care. Selank — Evidence base: modest and concentrated in provenance, with gene expression as the primary readout rather than behavioural or clinical endpoints. Search results require manual filtering because of name collisions.
All products sold on this website are intended for research and identification purposes only. These products are not intended for human dosing, injection, or ingestion.
Comparison generated from Lyra Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.