Neuroactive
Semax
Semax (ACTH 4-10 analog)
Also known as Met-Glu-His-Phe-Pro-Gly-Pro
Semax is a synthetic analog of ACTH fragment 4-10, extended with a C-terminal Pro-Gly-Pro sequence that markedly increases stability against peptidase degradation. The design goal was retention of the neurotropic effects attributed to the ACTH fragment while eliminating its corticotropic activity — the fragment does not stimulate steroidogenesis. Published work reports rapid upregulation of BDNF and NGF expression in hippocampal tissue. As with Selank, most primary literature is Russian-language and requires translation.
Research applications
- BDNF and NGF expression profiling in hippocampal tissue
- Dopaminergic and serotonergic system interaction studies
- Neuroprotection assays in ischemia models
- Peptidase stability studies of Pro-Gly-Pro extended analogs
Storage
Store lyophilized at -20°C protected from light. Reconstituted at 2-8°C for up to 30 days.
Reconstitution
Reconstitute with bacteriostatic water down the vial wall. Swirl gently.
Published literature
211 papers indexed on PubMed for Semax. Showing 6, reviews first.
- 01Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions
Rahman OF et al. · J Am Acad Orthop Surg Glob Res Rev · 2026
- 02Therapeutic peptides in gerontology: mechanisms and applications for healthy aging
Mavrych V et al. · Front Aging · 2026
- 03[Place of oligopeptide H-Met-Glu-His-Phe-Pro-Gly-Pro-OH in the therapy and rehabilitation of patients with ischemic stroke]
Spirin NN et al. · Zh Nevrol Psikhiatr Im S S Korsakova · 2024
- 04Pharmacological Aspects of Neuro-Immune Interactions
Tarasov VV et al. · Curr Pharm Des · 2018
- 05
- 06ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke
Filippenkov IB et al. · Biomedicines · 2024
Indexed from PubMed, 2026-07-19. We link to sources rather than reproducing them.
Related compounds
Selank
5–10mg · COA published
Heptapeptide analog of tuftsin studied for effects on BDNF expression and GABAergic signaling.
- Purity
- 99.161%
- 5 lab certificates
DSIP
5mg · COA published
Nonapeptide isolated from rabbit cerebral venous blood, studied for effects on delta-wave sleep architecture.
- Purity
- 99.627%
- 2 lab certificates
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How Semax compares
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Semax
From $49