GHK-Cu vs Wolverine Blend
Tissue Repair
GHK-Cu
Naturally occurring copper-binding tripeptide studied for extracellular matrix remodeling and gene expression modulation.
Tissue Repair
Wolverine Blend
Co-formulated pentadecapeptide and thymosin beta-4 fragment, the two most frequently co-administered compounds in tissue-repair literature, supplied in a single vial.
Side by side
| Dimension | GHK-Cu | Wolverine Blend |
|---|---|---|
| Molecular weight A 3.5× difference in mass — these are not comparable on a milligram-for-milligram basis. | 400.9 g/mol | 1419.53 g/mol |
| Size class | small molecule / short peptide | short peptide |
| CAS number | 89030-95-5 | 137525-51-0 / 77591-33-4 |
| Research area | repair | repair |
| Sequence | Gly-His-Lys · Cu(II) | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val / Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES |
| Available sizes | 50mg, 100mg | 10mg |
| Entry price | $39 | $69 |
| Cost per mg Cost per milligram differs by more than 3×. Compare against the concentrations your protocol actually requires, not the headline vial price. | $0.64 | $6.90 |
Mechanism
GHK-Cu
GHK is a tripeptide (glycyl-L-histidyl-L-lysine) present in human plasma that forms a high-affinity complex with copper(II). Plasma concentration declines markedly with age, which is the observation that originally drove research interest. Gene expression work has reported that GHK-Cu modulates a large number of human genes, and it is among the better-characterized peptides in dermatological and matrix biology literature.
Wolverine Blend
This blend combines BPC-157, a synthetic pentadecapeptide derived from a gastric juice protein, with TB-500, a synthetic fragment of thymosin beta-4. The two are the most frequently co-administered pair in the repair literature because they act through entirely different mechanisms: BPC-157 is studied for angiogenic signaling and cytoprotection, while TB-500 is studied for actin sequestration and cell migration. Co-formulation removes a reconstitution step; it is not a claim of synergy, and the underlying evidence for each compound remains separate.
Evidence quality
Mechanism is not the same as evidence. Where we have assessed the literature, the verdict is stated plainly.
GHK-Cu
Evidence base: coordination chemistry and matrix effects well characterized. Gene expression findings are broad and would benefit from independent replication with copper-only controls.
Full research reference →Research applications
GHK-Cu
- Collagen and glycosaminoglycan synthesis assays
- Gene expression profiling in fibroblast cultures
- Metalloproteinase and antiprotease balance studies
- Copper transport and chelation research
Wolverine Blend
- Comparative angiogenesis and cell-migration assays
- Tendon and ligament repair models
- Actin-sequestration versus cytoprotection pathway separation
- Co-administration protocol design
Common questions
What is the difference between GHK-Cu and Wolverine Blend?
GHK-Cu is naturally occurring copper-binding tripeptide studied for extracellular matrix remodeling and gene expression modulation. Wolverine Blend is co-formulated pentadecapeptide and thymosin beta-4 fragment, the two most frequently co-administered compounds in tissue-repair literature, supplied in a single vial. They differ in molecular weight (400.9 vs 1419.53 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, GHK-Cu or Wolverine Blend?
GHK-Cu is lower at approximately $0.64 per milligram at its best tier, against $6.90 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can GHK-Cu and Wolverine Blend be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should GHK-Cu and Wolverine Blend be stored?
Store lyophilized powder at -20°C protected from light. Characteristic blue coloration in solution is expected and indicates intact copper complexation. For Wolverine Blend: Store lyophilized powder at -20°C protected from light. Reconstituted solution stable at 2-8°C for up to 30 days.
Which has the stronger evidence base?
GHK-Cu — Evidence base: coordination chemistry and matrix effects well characterized. Gene expression findings are broad and would benefit from independent replication with copper-only controls. Where we have not published a formal evidence assessment, treat the literature as requiring your own appraisal.
All products sold on this website are intended for research and identification purposes only. These products are not intended for human dosing, injection, or ingestion.
Comparison generated from Lyra Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.