GHK-Cu vs KLOW Blend
Tissue Repair
GHK-Cu
Naturally occurring copper-binding tripeptide studied for extracellular matrix remodeling and gene expression modulation.
Tissue Repair
KLOW Blend
Four-compound co-formulation: the Glow trio of GHK-Cu, BPC-157 and TB-500, plus the α-MSH-derived tripeptide KPV, studied together in tissue-remodeling and inflammatory-signaling contexts.
Side by side
| Dimension | GHK-Cu | KLOW Blend |
|---|---|---|
| Molecular weight | 400.9 g/mol | 400.9 g/mol |
| Size class | small molecule / short peptide | small molecule / short peptide |
| CAS number | 89030-95-5 | 89030-95-5 / 137525-51-0 / 77591-33-4 / 67727-97-3 |
| Research area | repair | repair |
| Sequence | Gly-His-Lys · Cu(II) | Not published as a linear sequence |
| Available sizes | 50mg, 100mg | 80mg |
| Entry price | $39 | $124 |
| Cost per mg | $0.64 | $1.55 |
Mechanism
GHK-Cu
GHK is a tripeptide (glycyl-L-histidyl-L-lysine) present in human plasma that forms a high-affinity complex with copper(II). Plasma concentration declines markedly with age, which is the observation that originally drove research interest. Gene expression work has reported that GHK-Cu modulates a large number of human genes, and it is among the better-characterized peptides in dermatological and matrix biology literature.
KLOW Blend
KLOW extends the Glow formulation with KPV, the C-terminal tripeptide (residues 11-13) of alpha-melanocyte-stimulating hormone. GHK-Cu is studied for copper delivery and extracellular matrix remodeling, BPC-157 for angiogenic and cytoprotective signaling, and TB-500 for actin sequestration and cell migration; KPV adds a line of work on NF-κB pathway inhibition in epithelial models. Each vial holds 50mg GHK-Cu, 10mg BPC-157, 10mg TB-500 and 10mg KPV. Co-formulation is a handling convenience; each compound's evidence base stands on its own.
Evidence quality
Mechanism is not the same as evidence. Where we have assessed the literature, the verdict is stated plainly.
GHK-Cu
Evidence base: coordination chemistry and matrix effects well characterized. Gene expression findings are broad and would benefit from independent replication with copper-only controls.
Full research reference →Research applications
GHK-Cu
- Collagen and glycosaminoglycan synthesis assays
- Gene expression profiling in fibroblast cultures
- Metalloproteinase and antiprotease balance studies
- Copper transport and chelation research
KLOW Blend
- Extracellular matrix remodeling assays
- Inflammatory cytokine and NF-κB pathway studies
- Copper-peptide gene expression modulation
- Multi-pathway repair protocol design
Common questions
What is the difference between GHK-Cu and KLOW Blend?
GHK-Cu is naturally occurring copper-binding tripeptide studied for extracellular matrix remodeling and gene expression modulation. KLOW Blend is four-compound co-formulation: the Glow trio of GHK-Cu, BPC-157 and TB-500, plus the α-MSH-derived tripeptide KPV, studied together in tissue-remodeling and inflammatory-signaling contexts. They differ in molecular weight (400.9 vs 400.9 g/mol) and in the pathways they are studied against.
Which is more cost-effective per milligram, GHK-Cu or KLOW Blend?
GHK-Cu is lower at approximately $0.64 per milligram at its best tier, against $1.55 for the other. Cost per milligram is only meaningful relative to the concentrations a given protocol requires, since these compounds are not used at comparable masses.
Can GHK-Cu and KLOW Blend be studied together?
Combination designs appear in the published literature for a number of these compounds. Whether it is appropriate for a given protocol depends entirely on the model and endpoint. We supply research compounds and do not provide protocol guidance — consult the primary literature for your specific model.
How should GHK-Cu and KLOW Blend be stored?
Store lyophilized powder at -20°C protected from light. Characteristic blue coloration in solution is expected and indicates intact copper complexation. For KLOW Blend: Store lyophilized powder at -20°C protected from light. Copper-containing peptides are light-sensitive — keep vials in the carton. Reconstituted solution stable at 2-8°C for up to 30 days.
Which has the stronger evidence base?
GHK-Cu — Evidence base: coordination chemistry and matrix effects well characterized. Gene expression findings are broad and would benefit from independent replication with copper-only controls. Where we have not published a formal evidence assessment, treat the literature as requiring your own appraisal.
All products sold on this website are intended for research and identification purposes only. These products are not intended for human dosing, injection, or ingestion.
Comparison generated from Lyra Vital catalog data. Every specification is reconciled against the certificate of analysis for the shipped batch.